Poly(lactic acid): Synthesis, modification and applications in controlled drug delivery

Poly(lactic acid) (PLA) is the most promising biodegradable alternative to replace conventionalpetrochemical-based polymers in manufacturing high performance materials. Here we review main methods obtain polylactic acid and briefly discuss its functionalization application field of controlled drug release. We conducted a bibliographic search scientific databases summarized results research carried out by our group. show that commonly used PLA modifications delivery systems are with glycolic (GA) polyethylene glycol (PEG) through copolymerization or blending, where use compatibilizers essential for good adhesion. Active vectorization discussed as choice depends on size nanoparticle type disease be treated.